Blood Clotting Factors List, Names and Roles

Clotting factors are the crux and most essential components of hemostasis or simply blood clotting. This process of hemostasis is divided into primary and secondary hemostasis.
Primary hemostasis, which results in the formation of a soft platelet plug, involves vasoconstriction, platelet adhesion, platelet activation, and platelet aggregation.

Secondary hemostasis is primarily defined as the formation of fibrinogen into fibrin, which ultimately evolves the soft platelet plug into a hard, insoluble fibrin clot. Within primary and secondary hemostasis,

Blood clotting involves 3 coagulation pathways: intrinsic, extrinsic, and common pathways.

Coagulation requires these factors and enzymatic reactions to take place effectively. In this article we shall cover all these factors and their roles in various stages of blood clotting. If you want to learn more about blood clotting process you can check it here

What are the factors involved in the intrinsic pathway?

The factors involved in the intrinsic pathway include factors XII, XI, IX, and VIII.

What are the factors involved in the intrinsic pathway?

The extrinsic pathway includes factor VII, and III.

The common pathway includes clotting factor X, V, II, I, and XIII.

In the intrinsic pathway, factors XII, XI, IX, and VIII are also known as

Factor IV is a calcium ion that plays an important role in all 3 pathways. Some of these factors function as serine proteases, specifically factors II, VI, IX, and X. Majority are manufactured principally in hepatocytes (liver cells). The factors produced by the liver are: XIII, XII, XI, X, IX, VII, V, II, and I.

Factor VIII (antihemophilic factor A), and III (tissue factor) originate from endothelial cells, whereas clotting factor IV