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A rate-limiting enzyme is a key enzyme of which the activity determines the overall rate of a metabolic pathway.

1. Glycolysis : phosphofructokinase

2. Gluconeogenesis : PEP (phosphoenol pyruvate) carboxylase

3. Glycogenesis : glycogen synthase

4. Glycogenolysis : glycogen phosphorylase

5. Kreb cycle : isocitrate dehydrogenase

6. Ketone body synthesis : HMG co A synthase

7. Cholesterol synthesis : HMG co A reductase

8. Porphyrin synthesis : ALA synthase

9. Fatty acid synthesis : acetyl CoA carboxylase

10. Uric acid synthesis : xanthine oxidase


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