This is an idiosyncratic reaction to a wide variety of phenothiazines or butyrophenones such as haloperidol.

Muscular rigidity and rhabdomyolysis may occur as well. Treatment, besides stopping the drug, is with bromocriptine or dantrolene.

Central Core Disease (CCD) is a rare non progressive myopathy with autosomal dominant inheritance, presenting in infancy and characterized by hypotonia and proximal muscle weakness.

Five ‘Rs’ of intravenous fluid administration

• Resuscitation
• Routine maintenance
• Replacement
• Redistribution
• Reassessment

Red man syndrome is associated with rapid intravenous infusion vancomycin. It is a common adverse reaction of intravenous vancomycin use, and is a distinct entity from anaphylaxis due to vancomycin use.

Typical symptoms include redness, pruritus, and a burning sensation, predominantly in the upper body (face, neck, and upper chest). 
Severe cases can be associated with hypotension and chest pain.

The management of red man syndrome involves cessation of the infusion; and when symptoms have resolved, recommencement at a slower rate. 
In patients who are more symptomatic, antihistamines can be administered.  
Intravenous fluids may be required if the syndrome is associated with hypotension.

Diloxanide furoate is the drug of choice for asymptomatic patients with E. histolytica cysts in the faeces. Metronidazole and tinidazole are relatively ineffective.
Diloxanide furoate is relatively free from toxic effects and the usual course is of 10 days, given alone for chronic infections or following metronidazole or tinidazole treatment.

Biphasic pills are forms of COC pills containing two different dose combinations of oestrogen and
progestin usually in packets of 21 or 28 tablet e.g. in 21 active pills, 10 may contain one combination,
while 11 contain another. Examples include Biphasil, Ovanon, and Normovlar

Chvostek’s sign consists of twitching of muscles supplied by the facial nerve when the nerve is tapped about 2 cm anterior to the earlobe, just below the zygomatic arch.

When hypocalcemia develops from parathyroid disease, Chvostek’s sign, a facial spasm, may be an early symptom

Atopic dermatitis is a pruritic disease of unknown origin that usually starts in early infancy; approximately 85% of cases occur within first year of life. Usually presents with pruritus, eczematous lesions, xerosis (dry skin) and lichenification (thickening of skin)

Tactile or vocal fremitus is the palpable vibration you feel when the patient speaks (says ‘99’).

Assessment of tactile fremitus is used to evaluate airflow and density of underlying tissue. Normally, the thicker the chest wall, the more diminished the fremitus; the lower the voice pitch, the greater the fremitus.

Increased fremitus (low voice pitch): conditions causing fluid or exudates in lungs (e.g consolidating pneumonia, atelectasis, pulmonary fibrosis, pulmonary edema, or pulmonary infarction) and sometimes lung tumor depending on size and mobility.

Decreased or absent fremitus (high pich): air trapping, solid tissue, or decreased air movement (e.g. emphysema, asthma, pleural effusion, pneumothorax, or distal to airway obstruction)

In this condition the contractions of the uterus are irregular, infrequent and ineffectual.

The diagnosis is made by palpation and timing the length of contractions. Repeated vaginal examination will demonstrate a cervix which fails to dilate.

Contractions may be strengthened by rehydration, relaxation (e.g. by epidural anaesthesia), rupture of the membranes and the use of intravenous syntocinon.

Ig G
-Only antibody that pass placental circulation causing passive immunity.
-Short term protection.
-Has an Immediate action.
Ig A
–Present in all bodily secretions (tears, saliva, colostrums).
Ig M
–Acute in inflammation.
Ig E
–For allergic reaction.
Ig D
–For chronic inflammation

These are substances that promote cell division.
Many act locally as autocrines or paracrines

• Epidermal growth factor (EGF)
  
• Platelet-derived growth factor (PDGF)
  
• Fibroblast growth factor (FGF)
  
• Nerve growth factor (NGF)
  
• Tumor angiogenesis factors (TAFs)
  
• Insulin-like growth factor (IGF)
  
• Cytokines

Pancreatic islets (islets of Langerhans)

• Alpha cells (20%) produce glucagon
  
• Beta cells (70%) produce insulin
  
• Delta cells (5%) produce somatostatin
  
• F cells produce pancreatic polypeptide

Posterior pituitary gland does not synthesize hormones, but it does store and release two hormones made by the hypothalamus.

• Oxytocin (OT)
  
• Antidiuretic hormone (ADH)

Hormones of the anterior pituitary gland are;

• Human growth hormone (hGH)
  
• Thyroid-stimulating hormone (TSH)
  
• Follicle-stimulating hormone (FSH)
  
• Luteinizing hormone (LH)
  
• Prolactin (PRL)
  
• Adrenocorticotrophic hormone (ACTH)
  
• Melanocyte-stimulating hormone (MSH)

Stillbirth
Lung immaturity
Intrauterine growth restriction
Macrosomia
Prematurity
Underdevelopment (ie, sacral agenesis, ventricular septal defect, neural tube defect, cerebral palsy)
Shoulder dystocia
Hypoglycemia, Hypocalcemia, Hyperbilirubinemia

Power(ie, poor or uncoordinated uterine contractions)
Passenger(ie, fetus too large or malpresentation)
Passage (ie, pelvis too small or unusual shape)

Ectopy( ie, previous ectopic pregnancy)
PID(ie, pelvic inflammatory disease)
IUD(ie, intrauterine device)
Surgery (ie, previous lower abdominal surgery)
Endometri (ie, endometriosis)

HELLP Syndrome is a severe variant of pre-eclampsia

Hemolysis
Elevated Liver enzymes
Low Platelets

Analgesia is adequate
Bladder empty
Cervix is dilated
Descent past ischial spines
Ead (ie, head) presentation

Prolapse of umbilical cord
Placental abruption
Preterm labour
Presentation (ie, malpresentation)

Wind(ie, lung atelectasis)
Water ie, urinary tract infection)
Womb(ie, endomyometritis)
Wow (ie, mastitis)
Wind (ie, pneumonia)
Wound (ie, C-section or episiotomy site)
Walk (ie, deep venous thrombosis)

Multiple gestation
Age extremes (mother is younger or older)
Diabetes mellitus
Primigravida
Renal disease
Intrauterine growth restriction
Mole (ie, hydatidiform mole)
Increased blood pressure (ie, chronic hypertension)

Malignant melanoma
Breast
Thyroid
Kidney
Lung
Pants

Tumour (eg, retinoblastoma)
Hemorrhage (eg, traumatic posterior orbital hematoma)
Endocrinopathy (eg, Graves' disease)
Infection (eg, orbital cellulitis)

3rd nerve palsy
Anti-muscarinic eye drops (eg to facilitate fundoscopy)
Myotonic pupil (Holmes Adie pupil):most commonly in young women, with absent/delayed reaction to light and
convergence, and of no pathological significance.

All extraocular muscles are innervated by the third cranial nerve except the Lateral Rectus by the 6th cranial nerve and the Superior Oblique by the 4th cranial nerve

Long eyeball is ...
Myopic, requiring ...
Minus diopter lens for correction, and the patient is ...
Nearsighted

Trauma (eg, Colles' fracture, daily overuse at typing keyboard)
Endocrinopathy (ie, pregnancy, hypothyroidism, diabetes
mellitus, acromegaly)
Neurological (C5-C6 disk herniation can mimics a CTS)
Synovitis (eg, rheumatoid arthritis)

Passive stretching causes severe pain (moat reliable sign)
Pain
Pallor
Paresthesiae
Poor capillary refill
Pulselessness (late sign)

Type I: Straight through the epiphyseal growth plate
Type II: Above the epiphyseal growth plate (ie, in a fragment of metaphysis attached to the epiphysis)
Type III: Lower (ie, through and below the epiphyseal growth plate)
Type IV: Through the epiphysis and metaphysis
Type V: Emergency (ie, crush of the epiphyseal growth plate

Muscular dystrophy
Muscular atrophy (i.e., spinal muscle atrophy)
Myelodysplasia
Mcocutaneous syndromes (e.g., neurofibromatosis)
Arthrogryposis multiplex congenita
Cerebral palsy

Fainted
Illness/ Infantile febrile convulsions
Shock
Head injuries
Stroke (CVE)
Heart problems
Asphxia
Poisons
Epilepsy
Diabetes

Posturing (especially abnormal extensor thrusting)
Oropharyngeal problems (tongue thrusts, grimacing, W swallowing difficulties)
Strabismus
Tone increased or decreased in muscles
Evolutional responses (ie, persistent primitive reflexes or failure to develop equilibrium and protective responses)
Reflexes (ie, deep tendon reflexes are increased and plantar reflexes are up going.

In order to diagnose CP require four criteria in a child older than one year who has no evidence of a progressive disease by history

Hirschprung's disease, Hypothyroidism, Hypercalcemia
Anal fissure
Neurogenic bowel (eg, spina bifida)
Diabetes mellitus

Congenital abnormalities (eg, ventricular septal defect)
Chromosomal abnormalities (eg, Down's syndrome)
Cystic fibrosis
Celiac disease
Cow's milk protein intolerance (allergy)
Calorie-protein malnutrition
Cruelty (eg, parental neglect, abuse, environmental deprivation)

Rash (ie, purpuric rash over buttocks, estensor surfaces of legs, pre-tibial region)
Arthralgia
Sore abdomen
Hematuria
Hematochezia

Furunculosis
Acanthosis nigricans
Triad (1. diabetes mellitus, 2. atherosclerosis, 3. hypertension)
Slipped femoral capital epiphysis
Obesity in adulthood

Hypoxia
Hypoglycemia
Hypocalcemia
Hypomagnesemia
Hemorrhage (ie, periventricular, subarachnoid, subdural)
Infection (ie, fever, meningitis, TORCH organisms)

Cardiac abnormalities (specifically Coartication)
Lymphoedema
Ovaries underdeveloped (causing sterility, amenorrhea)
Webbed neck
Nipples

Fatty Liver
Anemia
Malabsorption
Edema

Skin color: blue or pink
Heart rate: below 100 or over 100
Irritability (response to stimulation): none, grimace or cry
Respirations: irregular or good
Tone (muscle): some flexion or active

Pulmonary hypoplasia
Oligohydrominios
Twisted skin (wrinkly skin)
Twisted face (Potter facies)
Extremities defects
Renal agenesis (bilateral)

Distressed
Drooling
Dysphagia
Dysphonia
Dyspnea

Accelerated growth (ie, height)
Breast development
Cunnus (vaginal) hair
Distal hair growth (ie, axillae)
Endometrial sloughing (ie, menarche)

Mnemonic - "Randy's Black Car Goes Putt Putt and Smokes"

Rifampin
Barbiturates
Carbamazepine
Grisoefulvin
Phenytoin
Phenobarb
Smoking cigarettes

Nicotinic effects: MTWTF (days of week):
Mydriasis/ Muscle cramps
Tachycardia
Weakness
Twitching
Hypertension/ Hyperglycemia
Fasiculation

Dopamine
Isoproterenol
Norepinephrine
Epinephrine
Dobutamine

Pregnancy
Allergy
Renal artery stenosis
K increase (hyperkalemia)

Stop the burning process
ABCs of basic life support
Visualize the patient for all injuries
Estimate burn size and begin fluid resuscitation
Airway (intubate if inhalation injury present)
Penicillin (i.e., start antibiotics)
Analgesic
Topical therapy (e.g., flumazanine cream)
Intoxicants/Inhalants
Nasogastric tube
Tetanus toxoid

Wear splints at night
Rest
Inject steroid
Surgical decompression
Take diuretics

Entire Head: 9%
Entire trunk: 18% + 18% = 36%
Entire arm: 9%
Entire leg: 18%
Whole body: 100%

Have you ever tried to Cut down on your drinking?
Do people ever Anger you about your drinking?
Do you ever feel Guilty about your drinking?
Do you ever require an Eye opener (ie, drink of alcohol) to get going in the morning?

Confusion
Blurred vision
Reduced lacrimation
Reduced salivation
Heart acceleration (tachycardia)
Urinary retention
Constipation

Acute onset, then fluctuation over days
2. Inattentiveness (especially to conversation)
3. Disorganized thinking (ie, incoherent speech)
4. State of consciousness either reduced or hypervigilant

For diagnosis of delirium need both 1 and 2 + either 3 or 4 (sensitivity 94-100%, specificity 90-95%)

Appetite diminished +/- weight loss
Sleep disturbance (especially diminished number of sleep hours)
Sexual libido diminished
Energy diminished
SuicidalitySelf-worthlessness and guilt
Psychomotor agitation
Anhedonia
Thought process impaired

Scanning and vigilance
Two or more worries
Organic causes should be ruled out
Motor tension
Anxiety unrelated
Course of mood or psychotic should be ruled out
Hyperactive autonomics

Vertigo
Ataxia
Nystagmus
Intention tremor
Stupor
Hperreflexia
Leukocytosis
Insipidus (ie, nephrogenic diabetes insipidus)
T-wave inversion on the electrocardiogram
Heaviness (ie, weight gain), Hypothyroidism, Hyperparathyroidism

Grandiosity
Racing thoughts
Euphoria
Activities, goal-directed
Talkative
Sleep deprived
Activities, reckless
Disractibility

Cognitive function (calculation, concentration, insight, judgment)
Overview (appearance, attitude, level of consciousness, movements)
Memory (recent and remote)
Orientation (to person, place & time)
Emotion (affect & mood)
Speech (fluency, form, & comprehension)
Thought (process, content, & perceptual disturbances)
Attention (abstract thinking, recall, and intelligence)
Something else (that might be important to the patient)

Insomnia and nightmares
Re-experiences of traumatic event at a later date
Arousal is increaseda
Numbing of general responsiveness to the real world

Propranolol
Reserpine
Oral contraceptives
Methyldopa
Steroids

Drugs
Encephalitis
Metabolic (eg, electrolyte or liver abnormality, dehydration, acute intermittent porphyria)
Endocrine (thyroid disease, diabetes mellitus)
Normal-pressure hydrocephalus
Trauma (eg, chronic subdural hematoma)
Infection (eg, of lung or urine, AIDS, syphilis)
Affective disorder (ie, depression manifesting as pseudodementia)
Structural defect of brain (eg, infarction, tumour, abscess)

Anticholinergic (see above for Anticholinergic Drug Side Effects)
Antihistaminic (eg, sedation, weight gain)
Ani-alpha 1 adrenergic (eg, orthostatic hypotension)
Arrhythmogenic (eg, quinidine-like ventricular cardiac effects)

Mucous plug
Asthma,
Aspiration, RDS
Pulmonary embolus,
Pneumonia,
Pneumothorax,
Pulmonary edema,
Psychogenic
Sepsis

Fibroses of lung
Infections (e.g., lung abscess, bronchiectasis, infective endocarditis)
Neoplastic (e.g., lung adenocarcinoma)
Gastrointestinal (e.g., chronic liver disease, inflammatory bowel disease, celiac disease)
Endocrine (e.g., hyperthyroidism)
Renal disease (chronic)
Cardiac (i.e., cyanotic congenital cardiac disease)

When cough in nursery, rock the "CRADLE"
Cystic fibrosis
Rings, slings, and airway things (tracheal rings)/ Respiratory infections
Aspiration (swallowing dysfunction, TE fistula, gastroesphageal reflux)
Dyskinetic cilia
Lung, airway, and vascular malformations (tracheomalacia, vocal cord dysfunction)
Edema (heart failure)

Metabolic (ie, gout, pseudogout, hemochromatosis)
Endocrine (ie, acromegaly)
Degenerative (ie, osteoarthritis)
Infectious (ie, septic joint, infectious synovitis, rheumatic fever)
Connective tissue disorders (rheumatoid factor-positive) (i.e, systemic lupus erythematosus, rheumatoid arthritis, progressive systemic sclerosis/scleroderma, polymyositis/dermatomyositis)
Inflammatory vasculitides (ie, polyarteritis nodosa, Wegener's granulomatosis, hypersensitivity vasculitis, giant cell arteritis)
Seronegative spondyloarthropathies (rheumatoid factor-negative) (ie, ankylosing spondylitis, Reiter's syndrome, psoriatic arthritis, inflammatory bowel disease)

Sepsis
Osteoarthritis
Fractures
Tendon/muscle
Epiphyseal
Referred
Tumor
Ischaemia
Seropositive arthritides
Seronegative arthritides
Urate
Extra-articular rheumatism (such as polymylagia)

Chorpromazine
Hydralazine
Isoniazid
Methyldopa
Procainamide

Osteophytes
Subchondral sclerosis
Subchondral cysts
Space between joint diminished

Cell count and differential
Crystal examination
Culture and Gram's stain

1. Photosensitivity
2. and 3. Rashes (ie, 2. Discoid rash; 3. Malar rash)
4. Ulcers in mouth
5. Neurologic (ie, seizures, psychosis)
6. and 7. Elevated blood tests (ie, 6. raised antinuclear antibody; 7. positive SLE cells seen, positive anti-double-stranded DNA antibody, positive antismooth muscle antibody, false-positive VDRL test)
8. Renal (ie, proteinuria, hematuria, cellular casts)
9. Arthritis (non-erosive)
10. Serositis (ie, pleuritis, pericarditis, peritonitis)
11. Hematologic (ie, hemolytic anemia, leukopenia, thrombocytopenia)

Note: Need 4 of 11 criteria for diagnosis of SLE

Delirium
Infection of urinary tract
Atrophic urethritis
Pharmacologic agents
Endocrine (e.g., glycosuria)
Restricted mobility ("geographic incontinence" of new setting)
Stool impaction

Delirium
Restricted mobility/ Retention
Inflammation / Infection/ Impaction [fecal]
Pharmaceuticals / Polyuria
"Drip" is convenient since it is urinary incontinence, so urine only drips out.

Acid-base problems (severe acidosis or alkalosis)
Electrolyte problems (hyperkalemia)
Intoxications
Overload, fluid
Uremic symptoms

Sclerderma
HIV nephropathy
Amyloidosis
Polycystic kidney disease
Endocrinophathy (diabetes)

Mnemonic - PLANE

Psychogenic: performance anxiety
Libido: decreased with androgen deficiency, drugs
Autonomic neuropathy: impede blood flow redirection
Nitric oxide deficiency: impaired synthesis, decreased
blood pressure
Erectile reserve: can't maintain an erection

Priapism
Phimosis
Paraphimosis
Peyronie's disease
Penile tumour
Purulence (ie, venereal disease)
Prostatitis
Push (ie, coitus-related trauma/overuse)

• CURLING- burns > 35% in body and fundus
  
• PHAGEDENIC ULCER/TROPICAL: vincets organism
  
• TROPHIC/PRESAURE SORES/NEUROGENIC MARTORELLES: hypertension
  
• BURILLIS: m.ulcerans/m.marinum
  
• MELENEYS: postoperative gangerene
  
• BAZINS:  localised fat necrosis
  
• CUSHINGS: raised ict
  
• CAMERON ULCERS- linear gastfic erosikns in hiatal hernia
  
• KISSING ULCER-both ant and post duodenal ulcers are present( seen in urinary bladder too)
  
• HUNNERS ULCER- interstitial cystitis
  
• MALENEYS ULCER- squamous cell cancer
  
• MARJOLINS ULCER-squamous cell cancer
  
• RODENT ULCER- basal cell cancer
  
• MOORENS ULCER- Moorens ulcer-corneal ulcer
  
• SEPTIC ULCER: slopping edge
  
• TB ULCER: undermined edge
  
• MALIGNANT ULCER-everted edge
  
• RODENT ULCER: pearly edge
  
• SYPHILITIC ULCER: puncuated edge

1. Artifactual as a result of hypoalbuminemia
   
2. Acute pancreatitis
   
3. Surgically induced hypoparathyroidism (transient or permanent)
   
4. Necrotizing fasciitis
   
5. Inadequate intestinal absorption
   
6. Excessive fluid losses from pancreatic or intestinal fistulae
   
7. Chronic diarrhea
   
8. Renal insufficiency with impaired calcium resorption
   
9. Hypomagnesemia
   
10. Hyperphosphatemia
    

Vincristine has a high neurotoxicity level and so must never be administered intrathecally, as it can cause ascending radiculomyeloencephalopathy -- which is almost always fatal.

Side Effects of corticosteroids

C - Cushing's syndrome

O - Osteoporosis

R - Retarded growth

T - Thin skin I - Immunosuppression

C - Cataracts

O - Oedema

S - Suppressed HPA axis

T - Thin gastric mucosa

E - Emotional

R - Rise in BP

O - Overweight

I - Increased hair

D - Diabetes

S - Striae

Metformin must be withheld before and for 48-hours after injection of IV contrast media - due to the increased risk of renal impairment, metformin accumulation, and lactic acidosis

Group A streptococci and S. aureus are the most common causes of impetigo

Necrotizing fasciitis is commonly associated with varicella infection, where the skin lesions are infected by Streptococcus or Staph

The right hemidiaphragm will appear higher on a lateral x-ray and a PA film because the liver pushes it upward

Interstitial Syndromes of the Lung include:
• Sarcoidosis
• Histiocytosis X
• IPF (interstitial pulmonary fibrosis)
• Tumor
• Failure
• Asbestosis
• Collagen disorders
• Environmental
• Dust
• Drugs

Tetracycline is an antibiotic.

Don't take with milk or other things containing calcium, bc will cause chelation and change absorption.

Also: Cholesteramine causes decreased absorption.

Quinidine is an anti-arrythmic drug.

It impairs Warfarin liver metabolism, so increases the amount of active Warfain, thus increasing INR and bleeding risk.

Also may be caused by decreased production of VitK in the gut.

Also: if taken with digoxin, binds to muscle tightly, so causes Dig Tox.

Probenecid inhibits uptake of uric acid in renal tubules.

Used in treatment of gout and to increase the action of penicillin and methotrexane (decrease excretion).

Phenobarbital is a barbituate.

It induces liver P450 enzymes that metabolize Warfarin. Thus, need to take more Warfarin when on this drug.

However, if taken patient off Penobarbital, INR rises, too much Warfarin effect.

Also: cholesteramine causes decreased abosorption.

Also: renal clearance is increased by alkalinization.

Penicillin use increase risk of bleeding when taking Warfarin.

2 possibilities

1) change gut flora, so decrease amt of VitK, so increase action of Warfarin.

2) inhibit liver enzyme responsible for Warfarin metabolism.

Also: cholesteramine causes decreased abosorption.

Also: excretion decreased by Probenecid and salicylate.

Methotrexate is used as chemo,

It can cause gout like symptoms from cell breakdown.

However, the drug is metabolized by xantine oxidase, so dont give with Allopruinol, as that would increase the effects of chemo.

Also: renal excretion decreased by Probenecid and Salicylate.

Lidocaine is given  with epinepherine to vasoconstrict and keept drug local.

Also: in CHF, increased action of the drug because decreased blood flow.

Erythromycin and other macrolides increase risk of bleeding when taking Warfarin. 2 possibilities 1) change gut flora, so decrease amt of VitK, so increase action of Warfarin. 2) inhibit liver enzyme responsible for Warfarin metabolism.

Also: increases Digoxin bioavailability by the above 2 mechanisms and also maybe inhibitin p-glycopritein transport system in kidney for Dig.

Epinephrine is given with lidocaine to vasoconstrict and keep the drug local.

Ditropan is an anticholinergic.

When taken with Amitriptyline, causes abdominal distension and constipation.

Because of a pharmacodynamic interaction : tricyclics inhibit the cholinergic system via a different mechanism.

Digoxin binds to muscle tissue, Vd=400.

If something else binds to muscle tissue, digoxin is displaced, leading to higher blood levels and lower Vd. = Digoxin toxicity. (eg, quinidine)

Also: Can cause increased bleeding if taken with Warfarin.

Also: Cholestyramine causes decreased absorption. Also: Erthromycin increases bioavail by 3 mechanisms.

Warfarin is an anti-coagulant, b/c reduces VitK dependent clotting factor production in the plasma.

It has a narrow therapeutic index: with a little Warfarin, the INR = 2, but with a little more, INR = 6+. Highly bound to plasma (95%).

Too much Warfarin leads to bleeding.

Interactions: Increased bleeding (asprin), GI bleeding (NSAIDS), Impairment of Warfarin metabolism and increased bleeding (Quinolone or phenytoin), increased bleeding, maybe bc less VitK (sulfa drugs). Bartituates like phenobarbital increase metabolism, so need more Warfarin.

Also: cholesteramine causes decreased abosorption.

Cholestyramine is an ion exchange binding resin. Used to lower cholesterol by disrupting enterohepatic circulation. It is a charged molecule, so it just sticks to the wall and blocks cholesterol absorption. Will also block the absorption of other drugs (decreased bioavail): such as digitalis, Warfarin, phenobarbitol, tetracycline, penicillin.

Calcium is found in milk etc. Ion, so can cause chelation. Ion binds to drug, gets trapped inside drug in a wierd shape.

It changes absorption of the drug (eg, Tetracycline).

Asprin works by inhibiting platlet function/ anti-thrombosis/ decreases vasoconstriction. 

Pharmacokinetic: Also, is highly bound to plasma (99%), so displaces Warfarin, leading to increased levels of Warfarin that is active. Therefore increases bleeding if taken with Warfarin.

Also: decreases renal excretion of Penicillin and Methotrexate by competing for the transport mechanism.

Amitriptyline is a tricyclic antidepressant. If taken with Ditropan (an anticholinergic), causes abdominal distension and constipation. Because of a pharmacodynamic interaction: tricyclics inhibit the cholinergic system also via diff mech. Also: tricyclics affect membrane pump that moves nts and antihypertensive drugs into intracellular storage sites. So may alter anti-HTN treatments. Also: metabolized via CYP 2D6, inhibited by Prozac.

Allopurinol is used in gout, xanthine-oxidase inhibitor. Xanthane-oxidase creates uric acid, but also metabolizes methotrexane. So, dont give this with methotrexane, even though it might be tempting to decrease gout symptoms in chemo. Also: Increased absorption if taken with iron.

Alcohol Induces CYP 2E1, increasing acetominophen toxicity.

Acetaminophen Can cause GI bleeding if taken with Warfarin. If taken with alcohol, increased hepatotoxicity.