Chronic Obstructive Pulmonary Disease (COPD) is a common, preventable, and treatable disease characterized by persistent respiratory symptoms and airflow limitation due to airway and/or alveolar abnormalities. These changes are typically caused by significant exposure to noxious particles or gases and are not fully reversible. COPD is often progressive and associated with chronic inflammation of the lungs.
Key Insight: Patients with COPD often describe the sensation of being "hungry for air."
Major Disease Entities
COPD includes the following primary conditions:
- Chronic Bronchitis: Defined clinically as a productive cough lasting at least 3 months in each of two consecutive years, in the absence of other causes.
- Emphysema: Defined pathologically as the permanent enlargement of airspaces distal to the terminal bronchioles, accompanied by destruction of alveolar walls.
- Asthma-COPD Overlap (ACO): A subset of patients show features of both asthma and COPD and may benefit from tailored therapy.
Epidemiology
- Prevalence (U.S.): ~13.9% in adults aged ≥25 years.
- Underdiagnosis: Up to 60% of cases may remain undiagnosed.
- Occupational Risk: 15–19% of cases are attributed to workplace exposures.
Etiology and Risk Factors
Primary Risk Factor:
- Cigarette smoking: Responsible for 80–90% of cases.
- Leads to:
- Reduced ciliary function
- Increased mucus production
- Alveolar destruction
- Chronic inflammation
- Leads to:
Other Contributing Factors:
- Environmental Exposure:
- Second-hand smoke
- Industrial dusts (grains, silica, coal)
- Chemical fumes/vapors
- Genetic Predisposition:
- Alpha-1 antitrypsin (AAT) deficiency : Autosomal codominant condition affecting 1–2% of COPD cases.
- History of respiratory infections in childhood
- Air pollution
- Low socioeconomic status
Pathophysiology
Emphysema:
- Destruction of alveolar walls → decreased surface area for gas exchange
- Loss of elastic recoil → airway collapse during exhalation
- Air trapping and hyperinflation → "barrel chest" appearance
- Types:
- Centrilobular (centriacinar): Primarily affects respiratory bronchioles (common in smokers).
- Panlobular (panacinar): Uniform involvement of alveoli, associated with AAT deficiency.
Chronic Bronchitis:
- Hypertrophy and hyperplasia of mucus-secreting glands
- Goblet cell proliferation → excess mucus
- Loss of cilia → impaired mucus clearance
- Airway narrowing due to inflammation
- Chronic hypoxia → polycythemia, cyanosis
Common Pathophysiological Changes:
- Increased airway resistance
- Impaired gas exchange (↓ PaO₂, ↑ PaCO₂)
- V/Q mismatch
- Chronic respiratory acidosis with metabolic compensation in advanced disease
Clinical Features
Shared Symptoms:
- Progressive dyspnea (initially on exertion, eventually at rest)
- Chronic cough (productive in bronchitis, dry in emphysema)
- Wheezing and chest tightness
- Fatigue and reduced exercise tolerance
Emphysema Dominant (Pink Puffer):
- Dyspnea predominant
- Minimal cough
- Thin body habitus
- Pursed-lip breathing
- Barrel chest
Chronic Bronchitis Dominant (Blue Bloater):
- Productive cough
- Frequent infections
- Cyanosis
- Obesity
- Peripheral edema (cor pulmonale)
Diagnosis
1. Pulmonary Function Tests (PFTs)
- Key Diagnostic Criterion: Post-bronchodilator FEV₁/FVC ratio < 0.70 confirms persistent airflow limitation.
- ↓ FEV₁, normal or ↓ FVC
- ↑ Residual Volume (RV), ↑ Total Lung Capacity (TLC)
2. Arterial Blood Gases (ABGs)
- ↓ PaO₂, ↑ PaCO₂ (especially in chronic bronchitis)
- Compensated respiratory acidosis in advanced stages
3. Imaging
- Chest X-ray:
- Flattened diaphragm
- Hyperinflated lungs
- Increased retrosternal air space
- High-resolution CT (HRCT): Useful for emphysema detection and AAT deficiency assessment
4. Other Tests
- Alpha-1 antitrypsin levels in early-onset or family history cases
- Six-minute walk test or BODE index for prognosis
Management
Prevention:
- Smoking cessation is the most effective intervention.
- Avoid exposure to occupational and environmental irritants.
- Annual influenza vaccine and pneumococcal vaccine .
Pharmacological Treatment:
Bronchodilators:
- Short-acting beta-agonists (SABAs): e.g., albuterol
- Long-acting beta-agonists (LABAs): e.g., salmeterol
- Long-acting muscarinic antagonists (LAMAs): e.g., tiotropium
Inhaled Corticosteroids (ICS):
- Indicated in patients with frequent exacerbations, especially with eosinophilia
Combination Therapy:
- LABA + LAMA ± ICS depending on exacerbation history and symptom burden
Others:
- Phosphodiesterase-4 inhibitors (e.g., roflumilast) in severe chronic bronchitis
- Theophylline (rarely used due to narrow therapeutic index)
🫁 Oxygen Therapy:
- For PaO₂ ≤ 55 mmHg or O₂ saturation ≤ 88%
- Goal: Maintain SpO₂ > 90%
Non-Pharmacological:
- Pulmonary rehabilitation
- Nutritional support
- Breathing techniques: Pursed-lip breathing, diaphragmatic breathing
- Surgical options: Bullectomy, lung volume reduction surgery, lung transplantation (select cases)
Complications
- Pulmonary hypertension and right heart failure (cor pulmonale)
- Acute exacerbations (triggered by infection or environmental exposure)
- Respiratory failure
- Depression and anxiety
Patient Education
- Encourage smoking cessation programs
- Correct inhaler technique
- Recognize early signs of exacerbation
- Adhere to medications and pulmonary rehab
- Nutritional advice (avoid underweight or obesity)
High-Yield Pearls
- COPD is not fully reversible , unlike asthma.
- FEV₁ decline is slowed, not reversed , with smoking cessation.
- Hypercapnia is more common in chronic bronchitis .
- O₂ therapy must be titrated carefully to avoid suppressing hypoxic drive in CO₂ retainers.